Low-dose immunosuppression in a rat hind-limb transplantation model
نویسندگان
چکیده
منابع مشابه
Orthotopic Hind Limb Transplantation in the Mouse.
In vivo animal model systems, and in particular mouse models, have evolved into powerful and versatile scientific tools indispensable to basic and translational research in the field of transplantation medicine. A vast array of reagents is available exclusively in this setting, including mono- and polyclonal antibodies for both diagnostic and interventional applications. In addition, a vast num...
متن کاملOrthotopic hind-limb transplantation in rats.
Composite tissue allotransplantation (CTA) now represents a valid therapeutic option after the loss of a hand, forearm or digits and has become a novel therapeutic entity in reconstructive surgery. However, long term high-dose multi-drug immunosuppressive therapy is required to ensure graft survival, bearing the risk of serious side effects which halters broader application. Further progression...
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OBJECTIVE The peroxisome proliferator-activated receptor gamma activator pioglitazone has recently been reported to possess pleiotropic cardioprotective and renoprotective actions. We hypothesized that pioglitazone would reduce a dose of the immunosuppressant cyclosporine after heart transplantation, resulting in beneficial protective effects for both cardiac allografts and recipient kidneys. ...
متن کاملMelatonin attenuates lung injury in a hind limb ischemia-reperfusion rat model.
OBJECTIVE This study evaluated the protective antioxidant effect of melatonin on lung injury as a remote organ after skeletal muscle ischemia-reperfusion in rats. METHODS Thirty male Wistar rats were allocated randomly into three experimental groups: operated with no ischemia (Sham) group, ischemia-reperfusion group and ischemia-reperfusion+melatonin group. Hind limb ischemia was induced by c...
متن کاملElectrical impedance alterations in the rat hind limb with unloading.
OBJECTIVES Methods are needed for quantifying muscle deconditioning due to immobilization, aging, or spaceflight. Electrical impedance myography (EIM) is one technique that may offer easy-to-follow metrics. Here, we evaluate the time course and character of the change in single- and multi-frequency EIM parameters in the hind-limb suspension model of muscle deconditioning in rats. METHODS Sixt...
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ژورنال
عنوان ژورنال: Transplant International
سال: 2003
ISSN: 0934-0874,1432-2277
DOI: 10.1111/j.1432-2277.2003.tb00251.x